In the forwards, there are two personnel changes as Megan Hyland and Ellie Williamson join the starting line-up, while there is a positional change for Aicha Sutcliffe who moves to loosehead prop.
In the backs, Rianna Darroch starts at scrum-half, while Emily Norval and Claudia McLaren are promoted from the replacements to start on the wings.
Speaking ahead of the match, Smith said: “We’ve shown a lot of resilience in our recent performances but we need to ensure we come out firing in the first-half and take the chances when they arise.
“This week’s focus has been about consistency in our contact work and being more clinical when we have possession. Wolfhounds have been on an impressive winning streak but we showed in Cork that we can challenge them.
“The players are excited to run out in front of a home crowd again at Scotstoun and we’re determined to put in a performance to match that occasion.”
In the front row, Hyland packs down at hooker alongside Sutcliffe and Katie Lindsay, while Holland Bogan and Williamson link-up in the second row.
An unchanged back row sees Gemma Thomson, Eilidh MacGilvray and Emily Coubrough retain their places.
Darroch and Ceitidh Ainsworth reunite to form the half-back partnership, while Millie Warren and Briar McNamara continue in the midfield.
The back-three sees Poppy Mellanby named at full-back once again, while Norval and McLaren line-up on the wings.
Get along and support Glasgow Warriors this Saturday as they face Wolfhounds in the Celtic Challenge, with match tickets available HERE.
Glasgow Warriors Women team to face Wolfhounds in the Celtic Challenge at Scotstoun Stadium (Sunday 15 February, kick-off 2pm) – live on YouTube.
1. Aicha Sutcliffe
2. Megan Hyland
3. Katie Lindsay
4. Holland Bogan (co-captain)
5. Ellie Williamson
6. Gemma Thomson
7. Eilidh MacGilvray
8. Emily Coubrough
9. Rianna Darroch
10. Ceitidh Ainsworth (co-captain)
11. Emily Norval
12. Millie Warren
13. Briar McNamara
14. Claudia McLaren
15. Poppy Mellanby
Replacements
16. Shelley Main
17. Poppy Fletcher
18. Imogen Spence
19. Sophie Murphy
20. Freya Walker
21. Samaanther Taganekurukuru
22. Hannah Dunnett
23. Robynn Gibson