Jack Shearer returns to the starting XV at loosehead having missed last Friday’s defeat to Australia.
Seb Stephen gets his first start of the campaign having been utilised off the bench against England and Australia.
Joe Roberts and Matthew Urwin both drop to the bench after starting the opening two tournament fixtures.
Scotland U20 Men team to play South Africa U20 at Stadio San Michele on Wednesday (kick off 2.30pm BST/3.30pm local) – live on RugbyPassTV
15. Jack Brown (Edinburgh Rugby)
14. Nairn Moncrieff (Edinburgh Rugby)
13. Angus Hunter (Heriot’s Rugby)
12. Jack Hocking (Unattached)
11. Cameron van Wyk (Ayr RFC)
10. Isaac Coates (Edinburgh Rugby)
9. Hector Patterson (Edinburgh Rugby)
1. Jake Shearer (Glasgow Warriors)
2. Seb Stephen (Edinburgh Academical FC/Glasgow Warriors)
3. Jamie Stewart (Edinburgh Rugby)
4. Mark Fyffe (University of Edinburgh)
5. Charlie Moss (Montpellier)
6. Oliver Duncan (Edinburgh Rugby)
7. Freddy Douglas – Captain (Edinburgh Rugby)
8. Reuben Logan (Northampton Saints)
Replacements
16. Joe Roberts (Glasgow Warriors)
17. Will Pearce (Cardiff Metropolitan University/Bristol Bears)
18. Ollie Blyth-Lafferty (Edinburgh Rugby)
19. Bart Godsell (Loughborough University)
20. Oliver Finlayson-Russell (University of St Andrews)
21. Noah Cowan (Brunel University/Ealing Trailfinders)
22. Matthew Urwin (Glasgow Warriors)
23. Jed Findlay (Exeter Chiefs)